I have started to see a difference with Brock's anxiety, but have not started the Wisdom Supplement yet since I was using a different cognitive support supplement and didn't want to skew results. I am starting Wisdom once this bottle of Neutricks is finished. Brock does seem a little calmer, and has started to be more snuggly again vs. just standing in the hallway and whining. Thanks for the trial offer and the note that came with it, it was a nice touch!!